May 21: Additional nations across the globe report first cases

Countries begin exploring mass vaccination options. President Joe Biden rejects the idea of a quarantine to prevent the spread of monkeypox. UNAIDS warns nations against perpetrating stigmas as they combat the spread of the virus.

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May 14: Mpox cases are recorded in Portugal, Italy, and Canada

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May 28: As mpox vaccines are first issued, first mpox death is recorded